Below are a couple of questions that had been handed in that I wanted to share with you all. We are interested to hear your questions on the impact this trial may have for care and future research.
Why CXA-201?
CXA-201 has a broad spectrum of activity against gram-negative organisms, including and covering many Enterobacteriaceae including ESBLs, the extended-spectrum beta-lactamases. However, it's most exciting feature is that it is the most potent beta-lactam active against Pseudomonas aeruginosa, including strains resistant to other therapies. We envisage that CXA-201 will be a very useful addition to the antibiotic agents available to treat serious bacterial infections.
CXA-201's mechanism of action.
CXA-201, like other beta-lactams, irreversibly inhibits bacterial cell wall replication. Bacterial cell walls are very important for their structural integrity and inhibiting this process leads to bacterial cell death.
Enzymes that break down beta-lactamases could render organisms expressing these enzymes resistant to CXA-201. To guard against this, CXA-101 is co-formulated with tazobactam, a potent suicide inhibitor of most beta-lactamases, thereby protecting CXA-201 from hydrolysis and preserving its activity in organisms expressing ESBLs.
I'm proud and excited to play my part in the CXA-201 trial and I hope you are, too. Many thanks for all of your hard work in this trial!
Work, Life, Balance and the Working Mother
By the time I’ve taken care of my son and of my husband and worked all day I have no energy or time left for myself. There are so many responsibilities packed into one day for a working parent that you can sometimes find yourself feeling irritated, annoyed, and resentful. Today many employers are becoming more mindful of the fact that working parents need a better work/life balance. Some companies provide flex schedules, in house massages, and convenience services such as dry cleaning.
Many companies allow their employees to work from home one or more days per week, which is an easy way for you to spend more time in the morning and afternoon with your children rather than in standstill traffic.
Below are a few tips I have seen on my company website pertaining specifically to work, life, balance:
1. Use one calendar for all appointments. If you have a conference scheduled for Monday morning, you're not going to be late to work. Putting all of your appointments whether they involve the office or the family on one calendar makes it easier to avoid schedule conflicts and missing personal appointments. You'll also be able to notice if you're spending more time on work than on family with a quick glance at the calendar.
2. Make your family a priority. Although your family is the most important thing in your life, you might forget to show it. Devote your weekends and any free weekday evenings to family activities. Even if you can't plan a mid-week activity, make a quick phone call to your children to see how their school day went.
3. Take it easy. Work can become so hectic that you forget that you actually do like your job and the people around you. Leave some free time to relax and regroup between meetings so you don't stay in a constant state of stress. You'll be able to appreciate what you do and who you work with.
These are just a few tips that I saw and didn’t even know existed until I spoke with a friend in Human Resources. Most companies also have an Employee Assistance Program where you can find many more helpful free tips to help keep you organized and as stress free as possible.
Submitted by Diana Vergato
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